@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix ns1: <http://www.w3.org/ns/prov#> .
@prefix this: <http://purl.org/np/RAyX4jzhZzaYKMsvkyU1PhvIVHjCJENsDX0h3WkXKrv78> .
@prefix sub: <http://purl.org/np/RAyX4jzhZzaYKMsvkyU1PhvIVHjCJENsDX0h3WkXKrv78#> .
@prefix schema: <https://schema.org/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix nt: <https://w3id.org/np/o/ntemplate/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix orcid: <https://orcid.org/> .
@prefix bl: <https://w3id.org/biolink/vocab/> .
@prefix npx: <http://purl.org/nanopub/x/> .

sub:Head {
  this: a np:Nanopublication;
    np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo .
}

sub:assertion {
  <http://purl.obolibrary.org/obo/DOID_7148> bl:category bl:Disease .
  
  sub:association a rdf:Statement;
    rdf:object <http://purl.obolibrary.org/obo/DOID_7148>;
    rdf:predicate bl:treats;
    rdf:subject <https://identifiers.org/drugbank:DB06273>;
    rdfs:label "actemra r rheumatoid arthritis ra 1 1 adult patients with moderately to severely active rheumatoid arthritis who have had an inadequate response to one or more disease modifying anti rheumatic drugs dmards giant cell arteritis gca 1 2 adult patients with giant cell arteritis polyarticular juvenile idiopathic arthritis pjia 1 3 patients 2 years of age and older with active polyarticular juvenile idiopathic arthritis systemic juvenile idiopathic arthritis sjia 1 4 patients 2 years of age and older with active systemic juvenile idiopathic arthritis cytokine release syndrome crs 1 5 adults and pediatric patients 2 years of age and older with chimeric antigen receptor car t cell induced severe or life threatening cytokine release syndrome actemra r actemra r actemra r actemra r actemra r";
    bl:association_type bl:ChemicalToDiseaseOrPhenotypicFeatureAssociation;
    bl:provided_by <https://w3id.org/um/NeuroDKG>;
    bl:relation schema:TreatmentIndication .
  
  <https://identifiers.org/drugbank:DB06273> bl:category bl:Drug .
}

sub:provenance {
  sub:assertion ns1:wasAttributedTo orcid:0000-0002-1468-3557 .
}

sub:pubinfo {
  sub:sig npx:hasAlgorithm "RSA";
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCODwZkXojpEKwk7Ldj2oPPfCstvqrcpgCaTLo235K7ht9C7E1GCkLvUuL2b4VWXJTcZx/hxgDauR8hUeYq/lS6tfTL9yFZsnfl+PWYDyz7vv6N+wJVx2LL8bO6ntCjcOzvW2t2WUeF12Sb6b3I6uOYP0N8iQKts1WasY/yEYKAHQIDAQAB";
    npx:hasSignature "gGbgLDF/P+4RzyfAFxCorzRhJ6Zhr7qZz1AGE6j8J4mC5DNb+1L2zTLx6Q7fo1umxXALcT1Wxjo94+/+WjIdKTdODkgi7MO2cfDcaPmG0xJ1r1EIuu/YS+Gthhae/DTDfAIEcSwphpq3I5ewaMH+6zTVB0bJBu3B/iMtOdX8OV8=";
    npx:hasSignatureTarget this: .
  
  this: dcterms:created "2021-07-03T14:50:29.852+02:00"^^xsd:dateTime;
    dcterms:creator orcid:0000-0002-1468-3557;
    nt:wasCreatedFromProvenanceTemplate <http://purl.org/np/RANwQa4ICWS5SOjw7gp99nBpXBasapwtZF1fIM3H2gYTM>;
    nt:wasCreatedFromPubinfoTemplate <http://purl.org/np/RAA2MfqdBCzmz9yVWjKLXNbyfBNcwsMmOqcNUxkk1maIM>;
    nt:wasCreatedFromTemplate <http://purl.org/np/RAManV5GZI01JKzW_IPcfOXoiFTcZMmsV7qTCLkdzr4Gs> .
}