http://purl.org/np/RAwlUKOkdB0hlnEFIKDZZnj3Llnpi16vL85c7lnRd7t4w
.trig | .trig.txt | .jelly | .jelly.txt
@prefix this: <http://purl.org/np/RAwlUKOkdB0hlnEFIKDZZnj3Llnpi16vL85c7lnRd7t4w> .
@prefix sub: <http://purl.org/np/RAwlUKOkdB0hlnEFIKDZZnj3Llnpi16vL85c7lnRd7t4w#> .
@prefix drugbank: <http://identifiers.org/drugbank/> .
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@prefix pav: <http://purl.org/pav/> .
@prefix infores: <https://w3id.org/biolink/infores/> .
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@prefix pmid: <http://www.ncbi.nlm.nih.gov/pubmed/> .
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this: a np:Nanopublication;
np:hasAssertion sub:assertion;
np:hasProvenance sub:provenance;
np:hasPublicationInfo sub:pubInfo .
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sub:assertion {
drugbank:DB01175 a biolink:Drug;
rdfs:label "escitalopram";
biolink:category biolink:Drug .
mondo:0008114 a biolink:Disease;
rdfs:label "obsessive-compulsive disorder";
biolink:category biolink:Disease .
sub:association a biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation;
rdf:object mondo:0008114;
rdf:predicate biolink:treats;
rdf:subject drugbank:DB01175;
rdfs:label "Escitalopram showed favorable pharmacokinetics and good tolerability. It is the most 5-HT-selective among SSRIs, with little or no affinity for other transmitter transporters or receptors [59]. Compared to other SSRIs, escitalopram may have weak or minimal interactions with the cytochrome P450 system [60, 61]. In a randomized, double-blind, placebo-controlled 24-week trial in OCD, escitalopram (20 mg/day) was associated with an increase in response rate compared to placebo after 12 weeks. Other placebo-controlled studies consistently showed escitalopram-related treatment response [25, 30]. 20 mg/day escitalopram has also been associated with better OCD symptom remission compared to 40 mg/day paroxetine or placebo at week 12 [30]. Three different escitalopram dosages (5, 10, and 20 mg/day) were compared with a fixed, 20 mg/day dose of paroxetine in a 12-week study, in which escitalopram showed both greater efficacy and better tolerability [62].";
biolink:aggregator_knowledge_source infores:knowledge-collaboratory;
biolink:category biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation;
biolink:has_population_context sub:context;
biolink:publications pmid:30101713;
biolink:relation ncit:C94303 .
sub:context a biolink:Cohort;
rdfs:label "adults";
biolink:category biolink:Cohort .
}
sub:provenance {
sub:assertion prov:wasAttributedTo orcid:0000-0002-7641-6446 .
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npx:hasSignatureTarget this: .
this: prov:generatedAtTime "2022-09-16T11:53:46.825298"^^xsd:dateTime;
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ntemplate:wasCreatedFromTemplate <http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY> .
biolink: pav:version "2.3.0" .
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