@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix this: <http://purl.org/np/RAwjsqEsu2bJBHyfB-kOH2jPHZsFC8nC_nrpxI23O5_V4> .
@prefix sub: <http://purl.org/np/RAwjsqEsu2bJBHyfB-kOH2jPHZsFC8nC_nrpxI23O5_V4#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix orcid: <https://orcid.org/> .
@prefix nt: <https://w3id.org/np/o/ntemplate/> .
@prefix schema: <https://schema.org/> .
@prefix nkg: <https://w3id.org/um/neurodkg/> .
@prefix npx: <http://purl.org/nanopub/x/> .

sub:Head {
  this: a np:Nanopublication;
    np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo .
}

sub:assertion {
  sub:assertion a nt:AssertionTemplate;
    rdfs:label "Defining a drug indication with its context (NeuroDKG)";
    nt:hasStatement sub:st00, sub:st01, sub:st02, sub:st03, sub:st04, sub:st05, sub:st06,
      sub:st07, sub:st08, sub:st09, sub:st10, sub:st11, sub:st12, sub:st13, sub:st14 .
  
  sub:association a nt:LocalResource;
    rdfs:label "this association" .
  
  sub:associationRelation a nt:GuidedChoicePlaceholder;
    rdfs:label "provide the type of drug indication";
    nt:possibleValue schema:ApprovedIndication, schema:PreventionIndication, schema:TreatmentIndication,
      nkg:OffLabelIndication, nkg:SymptomaticReliefIndication .
  
  sub:cohort a nt:LocalResource;
    rdfs:label "the study cohort" .
  
  sub:cohortAgeLabel a nt:LiteralPlaceholder;
    rdfs:label "describe the life stage or age of the cohort (e.g. Adults)" .
  
  sub:cohortAgeMax a nt:LiteralPlaceholder;
    rdfs:label "describe the maximum age of the cohort (e.g. 80)" .
  
  sub:cohortAgeMin a nt:LiteralPlaceholder;
    rdfs:label "describe the minimum age of the cohort (e.g. 7)" .
  
  sub:hasPhenotype a nt:GuidedChoicePlaceholder;
    rdfs:label "provide additional phenotypes for the cohort";
    nt:possibleValuesFromApi "https://name-resolution-sri.renci.org/lookup?limit=10&string=" .
  
  sub:object a nt:GuidedChoicePlaceholder;
    rdfs:label "search for the disease it treats";
    nt:possibleValuesFromApi "https://name-resolution-sri.renci.org/lookup?limit=10&string=" .
  
  sub:publication a nt:UriPlaceholder;
    rdfs:label "add the URL of a publication supporting this association (doi, PubMed...)" .
  
  sub:readableassertion a nt:LiteralPlaceholder;
    rdfs:label "describe the assertion concisely (e.g. tylenol treats pain in adults patients)" .
  
  sub:st00 a rdf:Statement;
    rdf:object sub:readableassertion;
    rdf:predicate rdfs:label;
    rdf:subject sub:association;
    nt:statementOrder "0"^^xsd:integer .
  
  sub:st01 a rdf:Statement;
    rdf:object sub:subject;
    rdf:predicate rdf:subject;
    rdf:subject sub:association;
    nt:statementOrder "1"^^xsd:integer .
  
  sub:st02 a rdf:Statement;
    rdf:object sub:object;
    rdf:predicate rdf:object;
    rdf:subject sub:association;
    nt:statementOrder "3"^^xsd:integer .
  
  sub:st03 a rdf:Statement;
    rdf:object biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation;
    rdf:predicate biolink:association_type;
    rdf:subject sub:association;
    nt:statementOrder "19"^^xsd:integer .
  
  sub:st04 a rdf:Statement;
    rdf:object sub:associationRelation;
    rdf:predicate biolink:relation;
    rdf:subject sub:association;
    nt:statementOrder "6"^^xsd:integer .
  
  sub:st05 a rdf:Statement;
    rdf:object <https://w3id.org/um/NeuroDKG>;
    rdf:predicate biolink:provided_by;
    rdf:subject sub:association;
    nt:statementOrder "22"^^xsd:integer .
  
  sub:st06 a nt:OptionalStatement;
    rdf:object sub:publication;
    rdf:predicate biolink:publications;
    rdf:subject sub:association;
    nt:statementOrder "10"^^xsd:integer .
  
  sub:st07 a nt:GroupedStatement, nt:OptionalStatement;
    nt:hasStatement sub:st07a, sub:st07b, sub:st07c;
    nt:statementOrder "11"^^xsd:integer .
  
  sub:st07a a rdf:Statement;
    rdf:object sub:cohort;
    rdf:predicate biolink:has_population_context;
    rdf:subject sub:association;
    nt:statementOrder "12"^^xsd:integer .
  
  sub:st07b a rdf:Statement;
    rdf:object sub:cohortAgeLabel;
    rdf:predicate rdfs:label;
    rdf:subject sub:cohort;
    nt:statementOrder "13"^^xsd:integer .
  
  sub:st07c a rdf:Statement;
    rdf:object biolink:Cohort;
    rdf:predicate biolink:category;
    rdf:subject sub:cohort;
    nt:statementOrder "14"^^xsd:integer .
  
  sub:st08 a nt:OptionalStatement;
    rdf:object sub:cohortAgeMin;
    rdf:predicate schema:requiredMinAge;
    rdf:subject sub:cohort;
    nt:statementOrder "15"^^xsd:integer .
  
  sub:st09 a nt:OptionalStatement;
    rdf:object sub:cohortAgeMax;
    rdf:predicate schema:requiredMaxAge;
    rdf:subject sub:cohort;
    nt:statementOrder "16"^^xsd:integer .
  
  sub:st10 a nt:OptionalStatement, nt:RepeatableStatement;
    rdf:object sub:hasPhenotype;
    rdf:predicate biolink:has_phenotype;
    rdf:subject sub:cohort;
    nt:statementOrder "18"^^xsd:integer .
  
  sub:st11 a rdf:Statement;
    rdf:object rdf:Statement;
    rdf:predicate rdf:type;
    rdf:subject sub:association;
    nt:statementOrder "20"^^xsd:integer .
  
  sub:st12 a rdf:Statement;
    rdf:object biolink:Drug;
    rdf:predicate biolink:category;
    rdf:subject sub:subject;
    nt:statementOrder "23"^^xsd:integer .
  
  sub:st13 a rdf:Statement;
    rdf:object biolink:Disease;
    rdf:predicate biolink:category;
    rdf:subject sub:object;
    nt:statementOrder "24"^^xsd:integer .
  
  sub:st14 a rdf:Statement;
    rdf:object biolink:treats;
    rdf:predicate rdf:predicate;
    rdf:subject sub:association;
    nt:statementOrder "21"^^xsd:integer .
  
  sub:subject a nt:GuidedChoicePlaceholder;
    rdfs:label "search for the indicated drug";
    nt:possibleValuesFromApi "https://name-resolution-sri.renci.org/lookup?limit=10&string=" .
  
  rdf:Statement rdfs:label "association Statement" .
  
  rdf:object rdfs:label "has disease" .
  
  rdf:predicate rdfs:label "has predicate" .
  
  rdf:subject rdfs:label "has drug" .
  
  rdf:type rdfs:label "has type" .
  
  rdfs:label rdfs:label "has label" .
  
  schema:ApprovedIndication rdfs:label "An indication for a medical therapy that has been formally specified or approved by a regulatory body." .
  
  schema:PreventionIndication rdfs:label "An indication for preventing an underlying condition, symptom, etc." .
  
  schema:TreatmentIndication rdfs:label "An indication for treating an underlying condition." .
  
  schema:requiredMaxAge rdfs:label "participant maximum age is" .
  
  schema:requiredMinAge rdfs:label "participant minimum age is" .
  
  biolink:EvidenceType rdfs:label "EvidenceType" .
  
  biolink:association_type rdfs:label "has BioLink type" .
  
  biolink:category rdfs:label "is a" .
  
  biolink:description rdfs:label "is described by" .
  
  biolink:has_drug rdfs:label "uses drug" .
  
  biolink:has_phenotype rdfs:label "has phenotypes" .
  
  biolink:has_population_context rdfs:label "has population context" .
  
  biolink:id rdfs:label "has id" .
  
  biolink:negated rdfs:label "is negated" .
  
  biolink:provided_by rdfs:label "is provided by" .
  
  biolink:publications rdfs:label "has publications" .
  
  biolink:qualifiers rdfs:label "is qualified by" .
  
  biolink:relation rdfs:label "has relation" .
  
  nkg:OffLabelIndication rdfs:label "An indication found in off-label drug uses" .
  
  nkg:SymptomaticReliefIndication rdfs:label "An indication for only managing the symptoms of the condition" .
}

sub:provenance {
  sub:assertion prov:wasAttributedTo orcid:0000-0002-1501-1082 .
}

sub:pubinfo {
  sub:sig npx:hasAlgorithm "RSA";
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCR9fz0fKCdWOWC+pxhkQhEM/ppbdIYe5TLSdj+lJzSlv9mYBaPgrzVezSwwbmhlHBPDZa4/vHycU315BdmUGq+pXllp9+rWFfrb+kBJwhZjpG6BeyyXBsRFz4jmQVxl/ZYHilQTh/XalYzKkEAyTiEMPee4Kz61PaWOKH24CsnOQIDAQAB";
    npx:hasSignature "HHHQCcpDJL/gxRYqEAx2vjH0YGn93hTCttAnr6AIxKFRGvFba9SVGI0Fh6Z1A9bIjCSEEeeROYknc77niSwJZ+wSmmZlwFKjhpeA/PSzbEe+OF8VMu95Ps1HntK6RG997TZ1L0ae/aAEEs3GR3P7pDJuwP1JiByp4nYP2ul7w5Q=";
    npx:hasSignatureTarget this: .
  
  this: dct:created "2021-03-14T11:00:00+01:00"^^xsd:dateTime;
    dct:creator orcid:0000-0002-1501-1082 .
}