@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix ns1: <https://w3id.org/np/o/ntemplate/> .
@prefix this: <http://purl.org/np/RAshatPzeZvix6B6XKefZ5midNGuGW88Zu6mQ-zmnZJuU> .
@prefix sub: <http://purl.org/np/RAshatPzeZvix6B6XKefZ5midNGuGW88Zu6mQ-zmnZJuU#> .
@prefix schema: <https://schema.org/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix orcid: <https://orcid.org/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .

sub:Head {
  this: a np:Nanopublication;
    np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo .
}

sub:assertion {
  <http://purl.obolibrary.org/obo/DOID_1787> biolink:category biolink:Disease .
  
  sub:association a rdf:Statement;
    rdf:object <http://purl.obolibrary.org/obo/DOID_1787>;
    rdf:predicate biolink:treats;
    rdf:subject <https://identifiers.org/drugbank:DB00682>;
    rdfs:label "\"Warfarin sodium is contraindicated in:   Pregnancy Warfarin sodium is contraindicated in women who are pregnant except in pregnant women with mechanical heart valves, who are at high risk of thromboembolism [  see    Warnings and Precautions (5.7)    Use in Specific Populations (8.1 see  Use in Specific Populations (8.1) Warfarin sodium is contraindicated in patients with:   Hemorrhagic tendencies or blood dyscrasias Recent or contemplated surgery of the central nervous system or eye, or traumatic surgery resulting in large open surfaces [  see    Warnings and Precautions (5.8) Bleeding tendencies associated with:  - Active ulceration or overt bleeding of the gastrointestinal, genitourinary, or respiratory tract - Central nervous system hemorrhage - Cerebral aneurysms, dissecting aorta - Pericarditis and pericardial effusions - Bacterial endocarditis Threatened abortion, eclampsia, and preeclampsia Unsupervised patients with conditions associated with potential high level of non-compliance Spinal puncture and other diagnostic or therapeutic procedures with potential for uncontrollable bleeding Hypersensitivity to warfarin or to any other components of this product (e.g., anaphylaxis) [  see    Adverse Reactions (6) Major regional or lumbar block anesthesia Malignant hypertension    Pregnancy, except in women with mechanical heart valves. (  4 5.7 8.1  Hemorrhagic tendencies or blood dyscrasias. (  4  Recent or contemplated surgery of the central nervous system (CNS) or eye, or traumatic surgery resulting in large open surfaces. (  4,  5.8)  Bleeding tendencies associated with certain conditions. (  4  Threatened abortion, eclampsia, and preeclampsia. (  4  Unsupervised patients with potential high levels of non-compliance. (  4  Spinal puncture and other diagnostic or therapeutic procedures with potential for uncontrollable bleeding. (  4  Hypersensitivity to warfarin or any component of the product. (  4  Major regional or lumbar block anesthesia. (  4  Malignant hypertension. (  4\"";
    biolink:provided_by <https://w3id.org/um/NeuroDKG>;
    biolink:relation schema:MedicalContraindication .
  
  <https://identifiers.org/drugbank:DB00682> biolink:category biolink:Drug .
}

sub:provenance {
  sub:assertion prov:wasAttributedTo orcid:0000-0002-1468-3557 .
}

sub:pubinfo {
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    npx:hasSignatureTarget this: .
  
  this: dct:created "2021-08-23T12:41:53.913+02:00"^^xsd:dateTime;
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    ns1:wasCreatedFromProvenanceTemplate <http://purl.org/np/RANwQa4ICWS5SOjw7gp99nBpXBasapwtZF1fIM3H2gYTM>;
    ns1:wasCreatedFromPubinfoTemplate <http://purl.org/np/RAA2MfqdBCzmz9yVWjKLXNbyfBNcwsMmOqcNUxkk1maIM>;
    ns1:wasCreatedFromTemplate <http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY> .
}