[ { "@id": "http://purl.org/np/RAj_LA3PltngoaTW2toZu69GwrPeSmTns9MnQbVAdT0rM#provenance", "@graph": [ { "@id": "http://purl.org/np/RAj_LA3PltngoaTW2toZu69GwrPeSmTns9MnQbVAdT0rM#assertion", "http://www.w3.org/ns/prov#wasAttributedTo": [ { "@id": "https://orcid.org/0000-0002-7641-6446" } ] } ] }, { "@id": "http://purl.org/np/RAj_LA3PltngoaTW2toZu69GwrPeSmTns9MnQbVAdT0rM#pubInfo", "@graph": [ { "@id": "http://purl.org/np/RAj_LA3PltngoaTW2toZu69GwrPeSmTns9MnQbVAdT0rM#sig", "http://purl.org/nanopub/x/hasAlgorithm": [ { "@value": "RSA" } ], "http://purl.org/nanopub/x/hasPublicKey": [ { "@value": "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCR9fz0fKCdWOWC+pxhkQhEM/ppbdIYe5TLSdj+lJzSlv9mYBaPgrzVezSwwbmhlHBPDZa4/vHycU315BdmUGq+pXllp9+rWFfrb+kBJwhZjpG6BeyyXBsRFz4jmQVxl/ZYHilQTh/XalYzKkEAyTiEMPee4Kz61PaWOKH24CsnOQIDAQAB" } ], "http://purl.org/nanopub/x/hasSignature": [ { "@value": "Bdjx5MKrsv/C2EyfmCSUMrbTKJWJ+l/WF9iiqiPR/wmwb8JY7c6nbJ/Wd2ol08j3nZ0wyE3+jDYndR+u86dqh2LCG7x6XtSaXUfU1oi+t3CV9zC0VgjE6I4tcL+k5IPeQeZhAZPkhMJZwD3TKhumVpl6KyLa7CsENC3CDKAgRJs=" } ], "http://purl.org/nanopub/x/hasSignatureTarget": [ { "@id": "http://purl.org/np/RAj_LA3PltngoaTW2toZu69GwrPeSmTns9MnQbVAdT0rM" } ] }, { "@id": "http://purl.org/np/RAj_LA3PltngoaTW2toZu69GwrPeSmTns9MnQbVAdT0rM", "http://www.w3.org/ns/prov#generatedAtTime": [ { "@value": "2022-09-16T11:49:08.542168", "@type": "http://www.w3.org/2001/XMLSchema#dateTime" } ], "http://www.w3.org/ns/prov#wasAttributedTo": [ { "@id": "https://orcid.org/0000-0002-1501-1082" } ], "https://w3id.org/np/o/ntemplate/wasCreatedFromTemplate": [ { "@id": "http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY" } ] }, { "@id": "https://w3id.org/biolink/vocab/", "http://purl.org/pav/version": [ { "@value": "2.3.0" } ] } ] }, { "@id": "http://purl.org/np/RAj_LA3PltngoaTW2toZu69GwrPeSmTns9MnQbVAdT0rM#assertion", "@graph": [ { "@id": "http://identifiers.org/drugbank/DB00370", "@type": [ "https://w3id.org/biolink/vocab/Drug" ], "http://www.w3.org/2000/01/rdf-schema#label": [ { "@value": "Mirtazapine" } ], "https://w3id.org/biolink/vocab/category": [ { "@id": "https://w3id.org/biolink/vocab/Drug" } ] }, { "@id": "http://purl.obolibrary.org/obo/MONDO_0100081", "@type": [ "https://w3id.org/biolink/vocab/Disease" ], "http://www.w3.org/2000/01/rdf-schema#label": [ { "@value": "sleep disorder" } ], "https://w3id.org/biolink/vocab/category": [ { "@id": "https://w3id.org/biolink/vocab/Disease" } ] }, { "@id": "http://purl.org/np/RAj_LA3PltngoaTW2toZu69GwrPeSmTns9MnQbVAdT0rM#association", "http://www.w3.org/1999/02/22-rdf-syntax-ns#object": [ { "@id": "http://purl.obolibrary.org/obo/MONDO_0100081" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate": [ { "@id": "https://w3id.org/biolink/vocab/treats" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#subject": [ { "@id": "http://identifiers.org/drugbank/DB00370" } ], "@type": [ "https://w3id.org/biolink/vocab/ChemicalToDiseaseOrPhenotypicFeatureAssociation" ], "http://www.w3.org/2000/01/rdf-schema#label": [ { "@value": "Among TCAs, doxepin (sinequan) appears to be best suited for managing insomnia in healthy adults. Doxepin works as a selective antagonist to H(1) receptors, which promote the initiation and maintenance of sleep (Owen, 2009) (Table 2 contains information on trazodone and mirtazapine). Ultra-low doses of this drug (< 6 mg per day) significantly improve and sustain both maintenance and duration of sleep (Rojas-Fernandez and Chen, 2014; Weber et al., 2010). Another frequently prescribed TCA is amitriptyline, which as a long-term option is found to be effective for patients with ongoing sleep problems (Everitt et al., 2014; Pagel and Parnes, 2001)." } ], "https://w3id.org/biolink/vocab/aggregator_knowledge_source": [ { "@id": "https://w3id.org/biolink/infores/knowledge-collaboratory" } ], "https://w3id.org/biolink/vocab/category": [ { "@id": "https://w3id.org/biolink/vocab/ChemicalToDiseaseOrPhenotypicFeatureAssociation" } ], "https://w3id.org/biolink/vocab/has_population_context": [ { "@id": "http://purl.org/np/RAj_LA3PltngoaTW2toZu69GwrPeSmTns9MnQbVAdT0rM#context" } ], "https://w3id.org/biolink/vocab/publications": [ { "@id": "http://www.ncbi.nlm.nih.gov/pubmed/31622593" } ], "https://w3id.org/biolink/vocab/relation": [ { "@id": "http://purl.obolibrary.org/obo/NCIT_C94303" } ] }, { "@id": "http://purl.org/np/RAj_LA3PltngoaTW2toZu69GwrPeSmTns9MnQbVAdT0rM#context", "@type": [ "https://w3id.org/biolink/vocab/Cohort" ], "http://www.w3.org/2000/01/rdf-schema#label": [ { "@value": "Adults" } ], "https://w3id.org/biolink/vocab/category": [ { "@id": "https://w3id.org/biolink/vocab/Cohort" } ] } ] }, { "@id": "http://purl.org/np/RAj_LA3PltngoaTW2toZu69GwrPeSmTns9MnQbVAdT0rM#Head", "@graph": [ { "@id": "http://purl.org/np/RAj_LA3PltngoaTW2toZu69GwrPeSmTns9MnQbVAdT0rM", "http://www.nanopub.org/nschema#hasAssertion": [ { "@id": "http://purl.org/np/RAj_LA3PltngoaTW2toZu69GwrPeSmTns9MnQbVAdT0rM#assertion" } ], "http://www.nanopub.org/nschema#hasProvenance": [ { "@id": "http://purl.org/np/RAj_LA3PltngoaTW2toZu69GwrPeSmTns9MnQbVAdT0rM#provenance" } ], "http://www.nanopub.org/nschema#hasPublicationInfo": [ { "@id": "http://purl.org/np/RAj_LA3PltngoaTW2toZu69GwrPeSmTns9MnQbVAdT0rM#pubInfo" } ], "@type": [ "http://www.nanopub.org/nschema#Nanopublication" ] } ] } ]