http://purl.org/np/RAZFqdakeGaMVnGpjTC_tRPZ1trWEeMiq8gy2y06u-nnk
.trig | .trig.txt | .jelly | .jelly.txt
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sub:assertion {
drugbank:DB01104 a biolink:Drug;
rdfs:label "sertraline";
biolink:category biolink:Drug .
mondo:0008114 a biolink:Disease;
rdfs:label "obsessive-compulsive disorder";
biolink:category biolink:Disease .
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rdf:subject drugbank:DB01104;
rdfs:label "Sertraline has shown efficacy and safety at doses of 50-200 mg/day [72] in treating phobic-related states, with a greater reduction in symptoms related to anxiety/fear, physical symptoms and avoidance behaviors [73]. Clinical improvements in obsessive symptoms and phobic behavior have been achieved with long-term therapy, with a good tolerability profile. A rapid sertraline titration up to 200 mg/day correlated with fast response rates. A 20-week study with sertraline 50-200 mg/day produced significant improvements both in functioning and social skills [74]. Stable sertraline treatment guaranteed lower recurrence rates, and a general improvement in quality of life. Placebo-controlled studies consistently showed sertraline-related treatment response [72, 75, 76], although with one exception [77]. Treatment of refractory OCD with high doses of sertraline (250-400 mg/day) resulted in a significant symptom improvement and a similar rate of adverse events observed with a 200 mg/day dose [78].";
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biolink:publications pmid:30101713;
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