@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix ns1: <https://w3id.org/np/o/ntemplate/> .
@prefix this: <http://purl.org/np/RAMhWTdQYm7-1lRytMlNJqguHNghQGKpNDZKTE44FkWNg> .
@prefix sub: <http://purl.org/np/RAMhWTdQYm7-1lRytMlNJqguHNghQGKpNDZKTE44FkWNg#> .
@prefix schema: <https://schema.org/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix orcid: <https://orcid.org/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .

sub:Head {
  this: a np:Nanopublication;
    np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo .
}

sub:assertion {
  <http://purl.obolibrary.org/obo/DOID_5844> biolink:category biolink:Disease .
  
  sub:association a rdf:Statement;
    rdf:object <http://purl.obolibrary.org/obo/DOID_5844>;
    rdf:predicate biolink:treats;
    rdf:subject <https://identifiers.org/drugbank:DB00445>;
    rdfs:label "\"ELLENCE is contraindicated in patients with:    Severe myocardial insufficiency  [see  Warnings and Precautions (5.1) Recent myocardial infarction or severe arrhythmias, or previous treatment with maximum cumulative dose of anthracyclines  [see  Warnings and Precautions (5.1) Severe persistent drug-induced myelosuppression  [see  Warnings and Precautions (5.4) Severe hepatic impairment (defined as Child-Pugh Class C or serum bilirubin level greater than 5 mg/dL)  [see  Warnings and Precautions (5.5) Severe hypersensitivity to ELLENCE, other anthracyclines, or anthracenediones  [see  Adverse Reactions (6.1)   Severe myocardial insufficiency ( 4 Recent myocardial infarction ( 4 Severe persistent drug-induced myelosuppression ( 4 Severe hepatic impairment ( 4 Severe hypersensitivity to ELLENCE, other anthracyclines, or anthracenediones ( 4\"";
    biolink:provided_by <https://w3id.org/um/NeuroDKG>;
    biolink:relation schema:MedicalContraindication .
  
  <https://identifiers.org/drugbank:DB00445> biolink:category biolink:Drug .
}

sub:provenance {
  sub:assertion prov:wasAttributedTo orcid:0000-0002-1468-3557 .
}

sub:pubinfo {
  sub:sig npx:hasAlgorithm "RSA";
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCODwZkXojpEKwk7Ldj2oPPfCstvqrcpgCaTLo235K7ht9C7E1GCkLvUuL2b4VWXJTcZx/hxgDauR8hUeYq/lS6tfTL9yFZsnfl+PWYDyz7vv6N+wJVx2LL8bO6ntCjcOzvW2t2WUeF12Sb6b3I6uOYP0N8iQKts1WasY/yEYKAHQIDAQAB";
    npx:hasSignature "GBGUgZEZXyxy3omh1cr3zgocpD5dRa4SjR0hHTMC216qt/42JKR3E2VPDKFnMWluW2eRSHG+jfjj9MeJUxKFGuGXvB5UUlvvtaKwJCiBp/J00qGsFiO0ZBU9VNlYBv+7XNwsBFji0Cw/oEq4lSn5q99oSB6wrNyniYvMGB9ILrc=";
    npx:hasSignatureTarget this: .
  
  this: dct:created "2021-08-25T13:53:02.725+02:00"^^xsd:dateTime;
    dct:creator orcid:0000-0002-1468-3557;
    ns1:wasCreatedFromProvenanceTemplate <http://purl.org/np/RANwQa4ICWS5SOjw7gp99nBpXBasapwtZF1fIM3H2gYTM>;
    ns1:wasCreatedFromPubinfoTemplate <http://purl.org/np/RAA2MfqdBCzmz9yVWjKLXNbyfBNcwsMmOqcNUxkk1maIM>;
    ns1:wasCreatedFromTemplate <http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY> .
}