@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix this: <http://purl.org/np/RAG8iYNGTYImSoN3Gkic0uJcwXsZT9kG5P1KxaUCon9D0> .
@prefix sub: <http://purl.org/np/RAG8iYNGTYImSoN3Gkic0uJcwXsZT9kG5P1KxaUCon9D0#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix orcid: <https://orcid.org/> .
@prefix nt: <https://w3id.org/np/o/ntemplate/> .
@prefix dao: <http://w3id.org/dao/> .
@prefix npx: <http://purl.org/nanopub/x/> .

sub:Head {
  this: a np:Nanopublication;
    np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo .
}

sub:assertion {
  dcterms:title rdfs:label "has name" .
  
  sub:action a nt:UriPlaceholder;
    rdfs:label "add the action {is-indicated-for-treatment-of|is-indicated-for-management-of|is-indicated-for-symptomatic-relief-of|is-indicated-as-adjunct-for|is-contraindicated-with|associated-with-risk-of} here";
    nt:hasPrefix "http://bio2rdf.org/";
    nt:hasPrefixLabel "the action";
    nt:hasRegex "{is-indicated-for-treatment-of|is-indicated-for-management-of|is-indicated-for-symptomatic-relief-of|is-indicated-as-adjunct-for|is-contraindicated-with|associated-with-risk-of|is-used-to-treat|may-treat}" .
  
  sub:assertion a nt:AssertionTemplate;
    rdfs:label "Drug Action template";
    nt:hasStatement sub:st0, sub:st1, sub:st2, sub:st3, sub:st4, sub:st5, sub:st6, sub:st7,
      sub:st8 .
  
  sub:context a nt:LiteralPlaceholder;
    rdfs:label "add any specified context for the drug action here" .
  
  sub:da a nt:LocalResource;
    rdfs:label "This drug action" .
  
  sub:drug a nt:UriPlaceholder;
    rdfs:label "add the drug identifier (Bio2RDF prefix:identifier) here";
    nt:hasPrefix "http://bio2rdf.org/";
    nt:hasPrefixLabel "the drug" .
  
  sub:evidence a nt:UriPlaceholder;
    rdfs:label "add the evidence type using the Evidence Ontology (https://www.ebi.ac.uk/ols/ontologies/eco) here";
    nt:hasPrefix "http://purl.obolibrary.org/obo/ECO_";
    nt:hasPrefixLabel "the type of evidence";
    nt:hasRegex "[0-9]{7}" .
  
  sub:phenotype a nt:UriPlaceholder;
    rdfs:label "add the phenotype/condition/disease/disorder/symptom/adverse event identifier (Bio2RDF prefix:identifier) here";
    nt:hasPrefix "http://bio2rdf.org/";
    nt:hasPrefixLabel "the phenotype" .
  
  sub:quote a nt:LocalResource;
    rdfs:label "This quoted text" .
  
  sub:quotedtext a nt:LiteralPlacehodler;
    rdfs:label "quote the supporting text here" .
  
  sub:source a nt:UriPlaceholder;
    rdfs:label "add the URL to the source (e.g. DailyMed URL) of the quoted text here" .
  
  sub:st0 a rdf:Statement;
    rdf:object dao:DrugIndication;
    rdf:predicate rdf:type;
    rdf:subject sub:da;
    nt:statementOrder "0"^^xsd:integer .
  
  sub:st1 a rdf:Statement;
    rdf:object sub:drug;
    rdf:predicate dao:drug;
    rdf:subject sub:da;
    nt:statementOrder "1"^^xsd:integer .
  
  sub:st2 a rdf:Statement;
    rdf:object sub:drugaction;
    rdf:predicate dao:drug-action;
    rdf:subject sub:da;
    nt:statementOrder "2"^^xsd:integer .
  
  sub:st3 a rdf:Statement;
    rdf:object sub:0000-0003-4727-9435;
    rdf:predicate dao:phenotype;
    rdf:subject sub:da;
    nt:statementOrder "3"^^xsd:integer .
  
  sub:st4 a rdf:Statement;
    rdf:object sub:context;
    rdf:predicate dao:context;
    rdf:subject sub:da;
    nt:statementOrder "4"^^xsd:integer .
  
  sub:st5 a rdf:Statement;
    rdf:object sub:quotedtext;
    rdf:predicate prov:value;
    rdf:subject sub:quote;
    nt:statementOrder "5"^^xsd:integer .
  
  sub:st6 a rdf:Statement;
    rdf:object sub:source;
    rdf:predicate prov:wasQuotedFrom;
    rdf:subject sub:quote;
    nt:statementOrder "6"^^xsd:integer .
  
  sub:st7 a rdf:Statement;
    rdf:object sub:source;
    rdf:predicate prov:wasDerivedFrom;
    rdf:subject sub:da;
    nt:statementOrder "7"^^xsd:integer .
  
  sub:st8 a rdf:Statement;
    rdf:object sub:evidence;
    rdf:predicate dao:evidence;
    rdf:subject sub:da;
    nt:statementOrder "8"^^xsd:integer .
  
  sub:title a nt:LiteralPlaceholder;
    rdfs:label "add the {drug} {action} {phenotype} here" .
  
  dao:context rdfs:label "has context" .
  
  dao:drug rdfs:label "has drug" .
  
  dao:drug-action rdfs:label "has drug action" .
  
  dao:evidence rdfs:label "has evidence" .
  
  dao:phenotype rdfs:label "has indication" .
  
  rdf:type rdfs:label "is a" .
  
  prov:wasDerivedFrom rdfs:label "was derived from" .
  
  prov:wasQuotedFrom rdfs:label "was quoted from" .
}

sub:provenance {
  sub:assertion prov:wasAttributedTo orcid:0000-0003-4727-9435 .
}

sub:pubinfo {
  sub:sig npx:hasAlgorithm "RSA";
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCTQs+mANCSHWhIW/YPio468UdGNHsPvADpjfaW8um/v2L4AoDIANginfoU65VNbPT5D0ADt1y0uFNne3VEMr9Y+I2HFaz6IKj+LdYMJk6VUf5WJoImRHIX6BZQwcUc22CbTBFYxvqvp3UmmHrCrhLIZjDSyutExK3tOTRoMDjGowIDAQAB";
    npx:hasSignature "FbXSmC4FMUqvkwR+3D1cVoEaaeqE8ipS2a5X3CHr7ModZW/OWpKk9YxdIF4MJj4kDlCDDnWpDiTjZeny3UyxsuKbeMrJxbdzGQV1ZouPG5A+2Az/JWA2MJexk6tN5KvO1EU5PjJ4yxAPpCb8PtEq99nD2SufUXcEiHcI+I8HQVo=";
    npx:hasSignatureTarget this: .
  
  this: dcterms:created "2020-04-14T13:13:44.817+01:00"^^xsd:dateTime;
    dcterms:creator orcid:0000-0003-4727-9435 .
}